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Jena RK  Yue CY 《Biomicrofluidics》2012,6(1):12822-1282212
This report studies the surface modification of cyclic olefin copolymer (COC) by 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer using photografting technique for the purpose of biointerface applications, which demonstrate resistance to both protein adsorption and cell adhesion in COC-based microfluidic devices. This is essential because the hydrophobic nature of COC can lead to adsorption of specific compounds from biological fluids in the microchannel, which can affect the results during fluidic analysis and cause clogging inside the microchannel. A correlation was found between the irradiation time and hydrophobicity of the modified substrate. Static water contact angle results show that the hydrophilicity property of the MPC-grafted substrate improves with increasing irradiation time. The contact angle of the modified surface decreased to 20 ± 5° from 88 ± 3° for the untreated substrate. The surface characterization of the modified surface was evaluated using x-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR spectroscopy). Attenuated total reflection-FTIR and XPS results show the presence of the phosphate group (P-O) on modified COC substrates, indicating that the hydrophilic MPC monomer has successfully grafted on COC. Finally, it was demonstrated that cell adhesion and protein adsorption on the MPC modified COC specimen has reduced significantly.  相似文献   
84.
Wang ZK  Zheng HY 《Biomicrofluidics》2012,6(1):12820-1282012
The study investigates the use of CO2 laser to induce glass strip peeling off to form microchannels on soda lime gass substrate. The strip peeling exhibits a strong dependence on the energy deposition rate on the glass surface. In spite of the vast difference in the combination of laser power and scanning speed, when the ratio of the two makes the energy deposition rate in the range 3.0-6.0 J/(cm2 s), the temperature rising inside glass will be above the strain point and reach the softening region of the glass. As a result, glass strip peeling is able to occur and form microchannels with dimensions of 20-40 μm in depth and 200-280 μm in width on the glass surface. Beyond this range, higher energy depsotion rate would lead to surface melting associated with solidification cracks and lower energy deposition rate causes the generation of fragment cracks.  相似文献   
85.
In order to construct the guidance strategy in a realistic nonlinear noise-corrupted interception endgame against a maneuverable target, a linearized zero-sum differential game is considered. Assuming perfect information in this game, sufficient conditions are established, which guarantee that a continuous interception strategy with memory (history-dependent) has the maximal capture zone. Two examples of such a strategy are analyzed: a modified super-twisting second-order sliding mode control and a modified integral sliding mode control. Simulation results of the original nonlinear interception endgame demonstrate that these strategies considerably reduce the chattering created by the classical game optimal bang-bang strategy without deteriorating the homing performance.  相似文献   
86.
The main purpose of the paper is to find out the provision of providing Networked Services (NSs) among National Institute of Technology (NIT) libraries in India. Methodology used for collecting data was questionnaire. The survey findings indicate that the majority of libraries prefer to provide communication network services (telephone, Internet, e-mail, facsimile etc), online journals (90%), automated catalog system (85%), multimedia databases (85%) and support (70%) services rather than the other services. Concerning the zone wise performance, south zone (80%) libraries are more potential than the other zone libraries in providing NSs.  相似文献   
87.
Homosexuality is now accepted as a normal variant of human sexuality, but homophobia among healthcare professionals is well documented. Establishment of trustful doctor–patient relationships is impossible in the presence of homophobia. We were interested to examine the extent of homophobia among medical students, the future doctors. This article aims to study attitudes of medical students of the University of Hong Kong towards homosexuality and to identify significant factors affecting their attitudes. A cross‐sectional study was performed on students of the University of Hong Kong. Attitudes towards homosexuality were compared between medical and non‐medical students. More than 25% of the medical students agreed with the statement ‘homosexuality is a psychological disorder that requires therapy’. More than 15% would avoid any physical contact with homosexuals to minimise the chance of contracting diseases, especially AIDS. Comparison between the medical students and non‐medical students showed that the attitudes of the medical students were significantly more homophobic. Factors explaining the difference included the importance of religion in the formation of moral values, gender, experience of working closely with homosexual friends, sexual orientation, experience of the heterosexual sexual act, acquaintance of homosexual friends, and experience of homosexual love relationships. In conclusion, there appeared to be a certain level of homophobia among the medical students. This could possibly be explained by their lack of experience of working closely with homosexual friends. Relevant curriculum modification and development are urgently needed, to provide ongoing opportunities for students to realise their own values that could unconsciously affect their clinical judgements.  相似文献   
88.
In two experiments, we investigated emergent conditional relations in pigeons using a symbolic matching-to-sample task with temporal stimuli as the samples and hues as the comparisons. Both experiments comprised three phases. In Phase I, pigeons learned to choose a red keylight (R) but not a green keylight (G) after a 1-s signal. They also learned to choose G but not R after a 4-s signal. In Phase II, correct responding consisted of choosing a blue keylight (B) after a 4-s signal and a yellow keylight (Y) after a 16-s signal. Comparisons G and B were both related to the same 4-s sample, whereas comparisons R and Y had no common sample. In Phase III, R and G were presented as samples, and B and Y were presented as the comparisons. The choice of B was correct following G, and the choice of Y was correct following R. If a relation between comparisons that shared a common sample were to emerge, then responding to B given G would be more likely than responding to Y given R. The results were generally consistent with this prediction, suggesting, for the first time in pigeons, the emergence of novel relations that involve temporal stimuli as nodal samples.  相似文献   
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The purpose of this study is to investigate the effect of computer-assisted learning integrated with metacognitive prompts on elementary students’ affective skills on the subject of electricity. The researchers developed educational software to enable students to easily and comprehensively learn the concepts in the subject of electricity. A case study method was used. Eighteen students from the seventh grade (12–13 years) participated in the study. Students’ views on their performances while using educational software and the impact of the software on their affective skills towards the subject of electricity were examined. Data were collected by open-ended questions in the educational software. According to the research results, there were students who had negative attitudes and perceptions before starting to learn about the subject of electricity. Interactive activities, animations, and visual experiments in the educational software were effective in overcoming the students’ negative attitudes and perceptions about the subject. Besides, students who assessed their own performances during the learning process believed themselves to be more successful over time. In the light of the research results, some suggestions are made for future studies.  相似文献   
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